Medication Review: How is Sarilumab Dosed & Administered for the Treatment of PMR & RA?

September 2025

In this educational video, Heather Mambretti, PA-C with over 13 years of rheumatology experience, explains how sarilumab is dosed and what patients can expect during administration for both rheumatoid arthritis (RA) and polymyalgia rheumatica (PMR). She discusses the convenience of the subcutaneous auto-injector, which allows patients to self-administer at home, and reviews the standard dosing regimen of 200 mg every two weeks with no loading dose required. Heather also addresses how to adjust to a lower 150 mg dose in the rare event of side effects such as neutropenia, thrombocytopenia, or hyperlipidemia. Patients will also learn what to expect with potential injection site reactions and why the first dose is often guided in the office before transitioning to home use. This overview provides practical insights into sarilumab dosing, patient support, and real-world considerations for managing RA and PMR. For more resources, visit the RhAPP website or download the RhAPP app.