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PublicationsPublications

ANCA-Associated Vasculitides in Systemic Sclerosis: A Unique Clinical Overlap with Significant Implications for Treatment and Outcomes

12/26/2025

CONCLUSION: AAV, predominantly microscopic polyangiitis with MPO-ANCA, can occur in SSc, particularly in patients with fibrosing ILD and anti-Scl70. Standard vasculitis treatments appear to be effective and do not worsen outcomes in SSc.

Treatment sequences of biological and targeted synthetic disease-modifying antirheumatic drugs for rheumatoid arthritis: a nationwide population-based study in France

12/24/2025

CONCLUSION: In this nation-wide analysis of 26 478 patients, TNFi was the most frequently dispensed first-line b/tsDMARD, with LT modulators and IL-6i preferred in second-line therapy.

A case report of wrist arthritis caused by Gemella haemolysans

11/22/2025

CONCLUSION: This case illustrates the potential limits of monotherapy with beta-lactams in native joint infections caused by G. haemolysans, especially in immunocompromised patients. The failure of amoxicillin may be explained by factors such as limited diffusion into joint tissues, the absence of surgical debridement, and the use of pharmacokinetic and pharmacodynamic breakpoints not specifically validated for this rare species. Early reassessment and combination therapy may be warranted,...

Natural history of clinical manifestations in activated phosphoinositide 3-kinase δ syndrome (APDS): Time-to-event analyses using the European Society for Immunodeficiencies-APDS registry

11/02/2025

Activated phosphoinositide 3-kinase delta (PI3Kδ) syndrome (APDS) is an ultra-rare, progressive disease characterised by immunodeficiency, immune dysregulation, and risk of malignancies. To further characterise the natural history of APDS, we analysed patient characteristics, manifestations, treatment use, and combinations of manifestations and combinations of treatments over time using longitudinal data from registration and follow-up visits in the European Society for Immunodeficiencies...

A case report of malignant hypertension and multiorgan dysfunction during immunotherapy for gallbladder cancer

10/29/2025

We report the case of a 77-year-old woman with metastatic gallbladder cancer who initially received adjuvant capecitabine following surgery. During this period, she developed a facial rash, associated with a positive antinuclear antibody (ANA) with a titer of 1:320. Six months later, disease recurrence prompted treatment with gemcitabine, cisplatin, and durvalumab. Shortly after completing six cycles of chemo-immunotherapy, she presented with rapidly progressive dyspnea, severe hypertension,...

ECOSBot: a multicenter validation pilot study of a generative AI tool for OSCE-based nephrology training

10/24/2025

CONCLUSIONS: ECOSBot reliably simulated both roles in nephrology OSCEs with high fidelity and strong alignment with expert rating. While challenges remain for subjective skill assessment, this tool offers a scalable and autonomous solution to enhance nephrology education.

Case Report: Pemetrexed-induced pseudocellulitis: a rare adverse effect to be recognized for better management

10/24/2025

Pseudocellulitis, a non-infectious inflammatory reaction mimicking infectious cellulitis, is a rare and often underrecognized adverse reaction to pemetrexed, frequently diagnosed late and leading to inappropriate treatments, particularly unnecessary antibiotic use. Through the presentation of a new case and a literature review conducted using Scopus and PubMed, we aim to clarify its clinical presentation and management. We report a new case of pemetrexed-induced pseudocellulitis (PIP), initially...

Topography of entheseal lesions on ultrasound: a comparative study between axial spondyloarthritis, psoriatic arthritis and healthy controls

10/15/2025

CONCLUSION: To distinguish SpA patients from controls, the sonographic scoring system used should account not only for the presence of specific entheseal lesions (structural and inflammatory) but also for the individual site affected.

Practical survey on the use of herbal medicine by patients with systemic sclerosis

08/05/2025

CONCLUSION: The practices reported were numerous and heterogeneous, although practitioners are not always aware of them. This point should be addressed more systematically during conventional medical management. The potential benefits for skin disorders could be explored further.

Combination Therapy Using Embolization, Gelified Alcohol Sclerotherapy, and Vertebroplasty to Treat Aggressive Vertebral Hemangioma: Technique and Initial Results

06/25/2025

The aim was to evaluate technical success, safety and effectiveness of a non-surgical protocol treatment combining transarterial embolization and percutaneous radiopaque gelified ethanol (RGE) sclerotherapy in a first procedure, followed by vertebroplasty in a second procedure, to treat patients with aggressive vertebral hemangioma (AVH). This retrospective study included a total of 10 patients treated for hemangiomas between September 2022 and March 2024. The 11 hemangiomas were located in the...

Percutaneous Pelvic Cementoplasty With or Without Screw Fixation in Patients Aged 70 Years and Over: Safety and Clinical Outcomes

06/23/2025

CONCLUSION: Percutaneous cementoplasty, with or without screw fixation, is a safe and effective technique for managing pelvic lesions in patients aged 70 years and older. It results in significant pain reduction and facilitates early mobilization, with most patients able to stand the day after the procedure.

Development of salivary gland organoids derived from patient biopsies: a functional model of Sjögren's disease

05/20/2025

CONCLUSIONS: We successfully developed SGOs from LSGBs of SjD patients, allowing long-term culture and faithfully recapitulating the disease phenotype. This model holds promise as a valuable tool for drug screening.

Impact of glucocorticoid tapering speed on renal outcomes in proliferative lupus nephritis: a multicentre retrospective study

05/13/2025

CONCLUSION: Rapid GC reduction to ≤7.5 mg/day within 6 months did not compromise renal outcomes or increase relapse in proliferative LN.

The effectiveness of a 3-week spa therapy on the 6-month mobility and functional ability of patients with knee osteoarthritis: the ANGELLO randomized controlled trial

05/13/2025

Spa therapy is a potential treatment for knee osteoarthritis (KOA). The primary objective of this randomized controlled trial (RCT) was to investigate the effectiveness of a 3-week spa therapy intervention on the 6-month change in function (mobility and functional ability) of KOA patients. Secondary objectives examined the effectiveness of the intervention on KOA-related pain, stiffness, overall symptoms severity, and patient's quality of life. Community-dwelling adults, aged 50-80 years-old...

From Risk Assessment to Management: Cardiovascular Complications in Pre- and Post-Kidney Transplant Recipients: A Narrative Review

04/12/2025

Kidney transplantation remains the best treatment for chronic kidney failure, offering better outcomes and quality of life compared with dialysis. Cardiovascular disease (CVD) is a major cause of morbidity and mortality in kidney transplant recipients and is associated with decreased patient survival and worse graft outcomes. Post-transplant CVD results from a complex interaction between traditional cardiovascular risk factors, such as hypertension and diabetes, and risk factors specific to...

Immune checkpoint inhibitors-induced large vessel vasculitis: clinical characteristics and management from a European multicentre study

03/26/2025

CONCLUSION: ICI-induced LVV is a rare, early-onset IrAE. Although continuation of ICIs may affect LVV outcomes, cancer progression remains the primary cause of mortality. Prospective studies are warranted to better balanced therapeutic approaches.

Ureaplasma urealyticum septic hip arthritis associated with ocrelizumab therapy in a young patient with multiple sclerosis

01/28/2025

No abstract

Comparison of Mesotherapy and Transcutaneous Electrical Nerve Stimulation (TENS) in the Management of Chronic Non-Specific Low Back Pain: A Randomized Clinical Trial

01/15/2025

Introduction-Aim: Chronic low back pain affects 80% of individuals at some point in their lives and has significant socioeconomic impacts. This study aims to compare the efficacy of mesotherapy with transcutaneous electrical nerve stimulation (TENS) in treating chronic low back pain.

Acute kidney injury as a key predictor of cardiovascular events in chronic kidney disease patients: the CKD-REIN study

12/16/2024

CONCLUSION: The findings of this study confirm that AKI is a significant independent predictor of MACE in CKD patients, demonstrating a strong severity-response relationship. These results underscore the importance of vigilant cardiovascular monitoring and preventive strategies in CKD patients following AKI episodes. Understanding the mechanisms linking AKI to cardiovascular outcomes is crucial for developing targeted interventions to mitigate these risks.

Enhancing vascular access planning in CKD: validating the 40% KFRE threshold for predicting ESKD in a French retrospective cohort study

10/18/2024

CONCLUSIONS: This study suggests that using a ≥40% 2-year KFRE threshold for planning vascular access in CKD patients is promising and potentially superior to the traditional <15 mL/min/1.73 m² eGFR threshold. This approach may offer a balance between minimizing premature AVF creation and the risk of starting dialysis via a central venous catheter.
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