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Effectiveness of Methotrexate and Leflunomide as Corticoid-Sparing Drugs

Danielle Gatti Palumbo, PharmD, presents a Journal Club discussion on a study evaluating the effectiveness of Methotrexate and Leflunomide as steroid-sparing drugs in patients with Polymyalgia Rheumatica (PMR). The study found that Leflunomide was more effective than Methotrexate in achieving steroid withdrawal and remission, with patients on Leflunomide achieving steroid discontinuation more quickly. Despite both treatments showing similar tolerability, Leflunomide demonstrated superior outcomes in terms of remission and faster steroid withdrawal. The study highlights Leflunomide as a promising option for PMR patients, though further research is needed to confirm these findings.

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