FAQ: What Is the Correlation of CD64 and IL-23 Expression in Inflamed Joint, Skin, and Gut Tissue?

January 2026

In this video, Lindsay Tom, PA-C, takes a focused look at the emerging connection between CD64 and IL-23 across inflamed joint, skin, and gut tissue. Drawing from real-world immunology and disease-state research, she explores why this pathway matters in immune-mediated inflammatory conditions such as psoriasis, psoriatic arthritis, and inflammatory bowel disease. The discussion highlights how CD64-expressing myeloid cells may influence inflammatory signaling, how this relationship shows up differently across tissues, and why these insights are shaping the way clinicians think about disease activity and treatment selection. This concise overview offers valuable perspective for APPs and clinicians looking to better understand the immunologic drivers behind these complex conditions and the therapies designed to target them. Visit the RhAPP Content Rheum or the RhAPP ACE 2.0 app for more rheumatology education.